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Monday, January 28, 2013

Hostess picks Little Debbie maker for Drake's

NEW YORK (AP) ? Hostess has picked the maker of Little Debbie as the lead bidder for its Drake's cakes.

According to a filing in U.S. bankruptcy court, McKee Foods has offered $27.5 million in cash for the cake brands, which include Devil Dogs, Funny Bones and Yodels. The fate of Twinkies and other Hostess cakes are still being negotiated with other bidders.

Hostess also said United States Bakery agreed to pay $28.9 million for its remained bread brands, which include Sweetheart, Eddy's, Standish Farms and Grandma Emilie's. That offer includes four bakeries, 14 depots and equipment. Earlier this month, Hostess picked Flowers Foods, which makes Tastykake and Nature's Own and Bunny bread, as the lead bidder for six of its major bread brands, including Wonder.

The "stalking horse" bid by McKee Foods would set the floor for an auction process that lets competitors make better offers. A judge would have to approve the final sale, which Hostess said is scheduled to close no later than May 30.

McKee's bid includes some equipment but not the Drake's bakery in Wayne, N.J. A spokesman for Hostess, Tom Becker, said the company continues "to market all remaining assets."

McKee Foods, based in Collegedale, Tenn., makes a variety of snack cakes under the Little Debbie banner that compete with Hostess cakes at a lower price. For example, its Cloud Cakes resemble Twinkies and its Devil Cremes resemble Devil Dogs. A representative for McKee Foods, Mike Gloekler, said the company didn't plan to scrap any brands as a result of the deal.

"Our intent is to produce like products as they are since they have different packaging and formulae," Gloekler said in a statement. He said McKee hoped to make Drake's products at its plant in Stuarts Draft, Va. since Drake's cakes are best known in the northeast region.

Hostess has said in court previously that it needed to move quickly in selling off its brands to capitalize on the outpouring of nostalgia and media coverage prompted by its demise. The company repeated the sentiment in its court filing Monday, noting that there is no advertising or marketing for Drake's brands, which also include Ring Dings, Sunny Doodles and Yankee Doodles.

"The longer Drake's products stay off the shelves, the more likely it is that consumers will begin to use competitors' products," the filing said.

McKee generates about $1.1 billion in sales a year, with its Little Debbie cake division accounting for $800 million of that, according to the company. In recent years, McKee has seen its sales remain flat or fall as eating habits have changed.

Hostess Brands Inc., based in Irving, Texas, has been plagued by even greater problems. The company announced in November that it was shutting down its business and selling its breads and snack cakes. Its demise came after years of management turmoil and turnover, with workers saying the company failed to invest its brands. Hostess filed for its second Chapter 11 bankruptcy in less than a decade this January, citing costs associated with its unionized workforce.

After declaring that it was going out of business, Hostess had solicited bids for its brands by a Dec. 10 deadline. The company said in its filing Monday that it had received one bid for "substantially all" of its assets. But Hostess said the bid was not as valuable as the combined total for of the bids it received for individual brands. In addition, Hostess said the bidder that made the offer for conducted "very limited diligence."

___

Follow Candice Choi at www.twitter.com/candicechoi

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-01-28-Hostess-Snack%20Cakes/id-6e262b1c976b45e0993bcfb930a885c0

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Jennifer Lawrence Comes Undone And More SAG Awards Highlights

The 'Silver Linings Playbook' actress suffered a wardrobe malfunction on the way to accept her statue.
By Amy Wilkinson

Jennifer Lawrence at the 2013 SAG Awards
Photo: Mark Davis

Source: http://www.mtv.com/news/articles/1700861/jennifer-lawrence-wardrobe-sag-awards-2013.jhtml

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Ohio gas prices still rising

COLUMBUS, Ohio (AP) -- Ohio motorists will see higher gas prices to start the work week.

The average price for a gallon of regular gas in Ohio was $3.39 in Monday's survey from auto club AAA, the Oil Price Information Service and Wright Express. That's 9 cents higher than a week ago.

Experts say prices are continuing to rise because of solid economic recovery in China and the U.S. and other factors.

The national average Monday was $3.35 ? about 4 cents higher than a week ago and 6 cents higher than this time last month.

The Ohio average is about the same as a year ago at this time.

The lowest average price in Ohio Monday was about $3.35 in the Toledo and Youngstown areas.

Source: http://news.yahoo.com/ohio-gas-prices-still-rising-155952924.html

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Peugeot halts Slovak output on weak demand

BRATISLAVA (Reuters) - France's carmaker PSA Peugeot Citroen halted production in Slovakia for the day on Monday and will add another four stoppage days next month in response to weak demand across Europe, the Slovak unit said.

Peugeot, which is cutting some 10,000 jobs and closing a domestic plant in France, is one of the key exporters in the central European country where growth is driven almost solely by the automotive production.

The carmaker, operating an assembly plant in the western Slovak town of Trnava where it makes the Peugeot 207 and Citroen C3 Picasso models, still expects production in Slovakia this year to exceed the 2012 output of almost 215,000 cars.

"Demand for new cars in Europe is continuously falling. Decreasing trends in sales transform into production cuts by several carmakers," PSA Peugeot Citroen Slovakia wrote in an emailed statement.

The Trnava plant has an annual production capacity of 300,000 vehicles.

The euro zone country's automotive industry is centered around assembly plants of Germany's Volkswagen , South Korea's Kia Motors Corp. and Peugeot.

Any production disruption in the sector could have a significant impact on the economy's performance, expected by the finance ministry to slow its expansion to 2.1 percent in 2013 from 2.5 percent this year on waning demand for its exports.

(Reporting by Martin Santa; Editing by Mike Nesbit)

Source: http://news.yahoo.com/peugeot-halts-slovak-output-weak-demand-111905430--finance.html

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Good Reads: 'purdah' culture in India, born good, finding purpose, a Jedi response

This week's good reads includes a young woman's perspective on India's 'purdah' culture, the morality of babies, on whether a life's purpose brings happiness, and an unusual petition to the White House for building a Death Star.

By Ben Arnoldy,?Staff Writer / January 21, 2013

Female staff members of a luxury hotel exhibit their skills after a 10-day self-defense course initiated by the hotel management and Delhi Police women?s wing in New Delhi, India, Jan. 17, 2013. A brutal rape of a 23-year-old student last month has sparked a national debate about the treatment of women and the inability of Indian law enforcement to protect them.

Altaf Qadri/AP

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?My first sense as a young girl of sexual menace came from my Indian grandfather. Let me be clear: He never even remotely sexually threatened or molested me. But he made sure I knew that the world in which I, a girl, was growing up was innately perilous to women.?

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Babies born good

Parents, it turns out that your bundles of joy could also be described as budding altruists. Writing for the Smithsonian magazine, Abigail Tucker writes on a heartwarming new area of research that?s finding babies showing preferences for ?good guys? over ?bad guys? and a proclivity to help and care for others.

?These findings may seem counterintuitive to anyone who has seen toddlers pull hair in a playground tunnel or pistol-whip one another with a plastic triceratops,? notes Ms. Tucker.

But a series of cleverly designed experiments at Yale and Harvard universities are seeing an orientation toward the good long before parents would seem to have had much chance to shape behavior.

The eureka moment for one researcher came while passing a ball back and forth with a toddler. The ball got away from the scientist, and rather than get it, he faked an inability to reach it. Seeing his struggle, the toddler got up to retrieve it for him. Other experiments involved puppet shows in which one color puppet is shown helping or hindering another. Eye-tracking tests found infants as young as 3 months old preferring the helper.?

Life, liberty, and the pursuit of meaning

Whether we are born with it, or taught it, altruism looks to be key to our well-being as adults.

Emily Esfahani Smith, writing for The Atlantic, highlights a new psychological study that suggests ?a meaningful life and happy life overlap in certain ways, but are ultimately very different.? Researchers interviewing 400 Americans found meaning in life to be tied up with being a ?giver,? while happiness was more linked with being a ?taker.? Meaning is also found in contemplating the future and the past, while happiness is fixated on the present ? and is consequently more fleeting.

From the nation?s foundational documents to the self-help aisles of bookstores, Americans are famously in pursuit of happiness. But that?s something of a mug?s game: ?Research has shown that having purpose and meaning in life increases overall well-being and life satisfaction, improves mental and physical health, enhances resiliency, enhances self-esteem, and decreases the chances of depression. On top of that, the single-minded pursuit of happiness is ironically leaving people less happy, according to recent research,? Ms. Smith writes.

The magazine goes on to cite data that roughly 40 percent of Americans have not found a ?satisfying life purpose.?

There will be no Death Star

A group of Internet pranksters raised the 25,000-plus signatures needed to get a response from the White House on their petition to have the US build a Death Star. The White House, to no one?s surprise, replied that the country would not be building the moon-shaped space station from the ?Star Wars? films that could blast planets into space dust. But the wording of the response, glorious it was.

?Why would we spend countless taxpayer dollars? ? $850,000,000,000,000,000, according to one study ? ?on a Death Star with a fundamental flaw that can be exploited by a one-man starship?? wrote Paul Shawcross, chief of the Science and Space Budget at the White House Office of Management and Budget, and arguably the best communicator to emerge from the intersection of space science, accounting, and the federal government.

This smooth-talking Jedi then went on to highlight the gee-whiz stuff the government and the private sector are doing in space.
?[W]e?ve got two spacecraft leaving the Solar System and we?re building a probe that will fly to the exterior layers of the Sun. We are discovering hundreds of new planets in other star systems and building a much more powerful successor to the Hubble Space Telescope that will see back to the early days of the universe.?

In other news, the White House has just upped the signature threshold for a response to 100,000.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/TFtKZzT7T9E/Good-Reads-purdah-culture-in-India-born-good-finding-purpose-a-Jedi-response

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Sunday, January 27, 2013

Playing it safe, Abbott leads at US championships

Jeremy Abbott competes during the senior men's short program at the U.S. figure skating championships, Friday, Jan. 25, 2013, in Omaha, Neb. (AP Photo/Charlie Neibergall)

Jeremy Abbott competes in the senior men's short program at the U.S. figure skating championships in Omaha, Neb., Friday, Jan. 25, 2013. (AP Photo/Nati Harnik)

Jeremy Abbott competes during the senior men's short program at the U.S. figure skating championships, Friday, Jan. 25, 2013, in Omaha, Neb. (AP Photo/Charlie Neibergall)

Jeremy Abbott competes in the senior men's short program at the U.S. figure skating championships in Omaha, Neb., Friday, Jan. 25, 2013. (AP Photo/Nati Harnik)

OMAHA, Neb. (AP) ? Patrick Chan and the Japanese can rest easy.

With just about everyone else stumbling, bumbling or worse, Jeremy Abbott's clean but conservative short program was more than enough to give him the lead in the splatfest that was the U.S. Figure Skating Championships on Friday night. The three-time champion finished with 84.10 points, and was three points ahead of Ross Miner going into Sunday's free skate.

Joshua Farris, the silver medalist at last year's junior world championships, was third.

"That was a lot of work," Abbott said. "I came into this championships knowing this would be more work than in the past. I got a late start to the season. My focus was just to do the best I could for now and move on to the world championships and make some magic happen there."

There certainly wasn't any magic Friday. Voodoo, maybe. Out of the 20 men, only four managed to get through their program without a major error.

Max Aaron and Farris were the first two skaters, and they got through unscathed. Impressive even, promising youngsters who could be factors in the next Olympic cycle. Farris attacked his program from the opening note, skating with the kind of fearless abandon contenders have to have. NBA players would have approved of the height he got on his jumps, and his triple axel and triple flip were solid. The landing on the first jump in his triple lutz-triple toe loop was shaky, but he managed to hang on.

"I'm a little petrified being up here right now," Farris said. "I'm so happy."

After Aaron and Farris, however, there were almost three hours of splats until Abbott skated.

And the guys they weren't necessarily botching quadruple jumps or other high-risk tricks. Former two-time junior world champ Adam Rippon fell on a triple flip-triple toe combination, jumps he can do in his sleep. Another fell out of a spin, the skating equivalent of tripping off a curb. Yet another looked as if he got lost on the way to the Olympic trials for swimming that were held here a few months back, belly-flopping onto the ice.

No wonder Olympic champion Evan Lysacek is contemplating a comeback.

Lysacek withdrew from nationals last week, saying he hadn't had enough time to train after hernia surgery in November. Even half-trained he probably still would have done better than most of this field.

While Abbott's program was perfectly respectable, he's going to have to crack it up a notch ? or 10 ? if he wants to have any chance at the podium at the world championships in March. He took the quad out of his short program a few weeks ago because of back problems, though he didn't need it Friday with everyone else falling.

He wasn't as mesmerizing as he normally is, either. Abbott has some of the finest skating skills in the world ? he should be certified as a master craftsman for his edgework ? and his step sequences alone are worth the price of admission. But he seemed a little flat, and it seemed to be accentuated by the techno music that was a big departure from the classical pieces that have become something of a trademark.

At least he stood up. When Abbottt landed his last jump, the triple axel, the audience broke into applause.

"For me today, it was about getting the job done and then really enjoying the rest of the performance," Abbott said. "Once I got that triple axel done, now we can start to have fun, the job is done and now it's about the performance."

Miner was third the last two years, and his bronze medal at NHK Trophy showed he was angling for an upgrade here. He had to skate right after Abbott, a spot that can either inspire or unnerve a skater.

For Miner, it was the former. He was clearly enjoying himself, smiling and racing around the rink with more energy than the Energizer Bunny. He doesn't quite have Abbott's polish ? few do ? but he made up for it with his enthusiasm.

His only flaw was a slightly underrotated quadruple salchow. But at least he was willing to risk it.

"Tonight was a little bit tentative for me," Miner said. "But I was happy I went out and skated a solid program."

That's more than most of the men can say.

Earlier Friday, Olympic silver medalists Meryl Davis and Charlie White won the short dance with a career-best 79.02 points.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-01-26-FIG-US-Championships/id-9a4aa71d98b04c86b7f20f2ff4fff919

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Saturday, January 26, 2013

Scientists find cancer-causing virus in the brain, potential connection to epilepsy

Friday, January 25, 2013

Researchers at Shriner's Hospital Pediatric Research Center at the Temple University School of Medicine, and the University of Pennsylvania have evidence linking the human papillomavirus 16 (HPV16) ? the most common cause of cervical cancer ? to a common form of childhood epilepsy. They have shown for the first time that HPV16 may be present in the human brain, and found that when they added a viral protein to the brains of fetal mice, the mice all demonstrated the same developmental problems in the cerebral cortex associated with this type of epilepsy, called focal cortical dysplasia type IIB (FCDIIB). The findings suggest that the virus could play a role in the development of epilepsy.

The results also mean that doctors may have to re-think their approach to treating this type of epilepsy, and perhaps consider other therapeutic options related to HPV, an infectious disease.

"This is a novel mechanism, and it fills a gap in our understanding about the development of congenital brain malformations," said Peter Crino, MD, PhD, Professor of Neurology at Temple University School of Medicine, and a member of Shriner's Hospital Pediatric Research Center, and the senior author of a recent report in the Annals of Neurology.

"If our data are correct, future treatment of cortical dysplasia could include targeted therapy against HPV16 infection, with the goal of halting seizures. Identifying an infectious agent as part of the pathogenesis of brain malformations could open up an array of new therapeutic approaches against various forms of epilepsy."

FCDIIB is a developmental malformation in the cerebral cortex, the area of the brain that plays key roles in thought, perception and memory. It is a common cause of both pediatric and adult epilepsy ? especially difficult-to-treat forms of epilepsy ? and it is thought to occur in the womb during early brain development. The condition is characterized by a disorganized cellular structure and enlarged, "balloon cells." Current treatments include surgery and medication.

Balloon cells contain a signaling cascade called the mammalian target of rapamycin complex 1 (mTOR1), which is important for cellular growth, proliferation and division, particularly in brain development. Other scientists have recently found the mTOR pathway is activated by the HPV16 E6 oncoprotein.

While there had never been any studies indicating that HPV16 could infect the brain, Dr. Crino saw a potential connection. "This is a sporadic, congenital brain malformation associated with mTOR signaling with no genetic predisposition," he said. "Based on various cellular and cell signaling similarities between cervical dysplasia and focal cortical dysplasia, this led me to a hypothesis that the HPV protein could be detected in FCDIIB."

To find out, the investigators first examined FCDIIB tissue samples from 50 patients for evidence of the HPV16 E6 protein. They found that all of the samples were positive for the protein in the balloon cells, but not in regions without balloon cells or in 36 control samples from healthy individuals.

They next examined the samples' genetic material by several sophisticated molecular techniques to look for evidence of HPV16 E6, and compared the findings to tissue from healthy controls and tissue from patients with different types of brain malformations and epilepsy. Again, every sample of FCDIIB was found to contain HPV16 E6 protein, whereas the control specimens and tissue from other types of dysplasia and conditions did not.

Finally, in a series of experiments, the scientists painstakingly delivered the E6 protein into the brains of fetal mice. "If E6 is the causative element for HPV cervical dysplasia and focal cortical dysplasia, putting the protein into a fetal mouse brain should disrupt the cortical development," Dr. Crino explained. When the scientists did this, they found that the fetal mouse brains did indeed develop brain malformations.

Dr. Crino plans to investigate other forms of cortical dysplasia to see if HPV or related viral proteins can be found. He and his team aren't sure how the virus gets into the brain, but their results suggest that an HPV infection in the placenta could be one possible path. The exact mechanism by which HPV16 might cause a malformation and epilepsy remains to be determined. He acknowledged several potential implications from the findings.

"We are going to have to think about this epidemiologically as an infectious disease, not a genetic disorder. In terms of prevention, with current HPV vaccination, we have a potentially modifiable disease," he said. "In addition, if in fact this type of epilepsy represents a disorder of mTOR signaling, then one strategy could be, rather than treating the patients with anti-epileptic drugs, is to perhaps use mTOR inhibitors.

"The million dollar result would be to show it is possible to induce a brain malformation with an E6 infection, and the animal develops epilepsy," Dr. Crino said. "It would be even better if we showed that it is preventable."

###

Temple University Health System: http://www.templehealth.org/

Thanks to Temple University Health System for this article.

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Source: http://www.labspaces.net/126452/Scientists_find_cancer_causing_virus_in_the_brain__potential_connection_to_epilepsy

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